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It has also been defined as increased amount of saliva in the mouth, which may also be caused by decreased clearance of saliva. [4] Hypersalivation can contribute to drooling if there is an inability to keep the mouth closed or difficulty in swallowing (dysphagia) the excess saliva, which can lead to excessive spitting.
A sialogogue (also spelled sialagogue, ptysmagogue or ptyalagogue) is a substance, especially a medication, that increases the flow rate of saliva. [1] The definition focuses on substances that promote production or secretion of saliva (proximal causation) rather than any food that is mouthwatering (distal causation that triggers proximal causation).
It works by increasing insulin release from the pancreas and decreases excessive glucagon release. [7] Exenatide was approved for medical use in the United States in 2005. [7] In 2019, it was the 312th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [10]
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M 1 and M 3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome .
In addition, the medication also works to help increase the effects of insulin on muscle cells, which take in glucose. [35] The medicine is not used for T1D as these patients do not produce any insulin and metformin relies on some insulin production in order to be effective. [ 34 ]
As a medication, insulin is any pharmaceutical preparation of the protein hormone insulin that is used to treat high blood glucose. [6] Such conditions include type 1 diabetes, type 2 diabetes, gestational diabetes, and complications of diabetes such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. [6]
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