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The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone marrow.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
While a number of biblical place names like Jerusalem, Athens, Damascus, Alexandria, Babylon and Rome have been used for centuries, some have changed over the years. Many place names in the Land of Israel, Holy Land and Palestine are Arabised forms of ancient Hebrew and Canaanite place-names used during biblical times [1] [2] [3] or later Aramaic or Greek formations.
The sheyd Ashmodai (אַשְמְדּאָי) in birdlike form, with typical rooster feet, as depicted in Compendium rarissimum totius Artis Magicae, 1775 Child sacrifice to the sheyd Molekh (מֹלֶךְ), showing the typical depiction of the Ammonite deity Moloch of the Old Testament in medieval and modern sources (illustration by Charles Foster for Bible Pictures and What They Teach Us, 1897)
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
Promegakaryocyte. A promegakaryocyte is a precursor cell for a megakaryocyte, the development of which proceeds as follows: [1]. CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte
The Apostolic Bible Polyglot is the first numerically coded Greek Old Testament. It allows study of both Hebrew- and Greek-based scriptural texts in the same language, and a student may follow the association of a word from either the New Testament to the Old Testament or vice versa.
Langhans giant cells are named for the pathologist who discovered them, Theodor Langhans. Like many of the other kinds of giant cell formations, epithelioid macrophages fuse together and form a multinucleated giant cell. The nuclei form a circle or semicircle similar to the shape of a horseshoe away from the center of the cell.