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Hair loss is originally seen in areas of repeated grooming or trauma, for instance the neck because of contact with a collar. Hair regrowth may occur, but the hair will be even weaker and the pattern will repeat. The dogs are affected between the ages of two and four years, and it is most commonly seen on the back towards the tail.
The mutation is the result of a Copy Number Variant, or duplication of certain instructions within a gene, that controls the distribution of pigment in a dog's hair follicle. As such, there are no genetic markers for red pigment. Dogs with a higher CNV were observed to have darker, richer colors such as deep gold, red, and chestnut.
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When a dog has wild-type alleles at all three genes, it will have a yellow coat. When the dog has a loss-of-function allele at MC1R, it will have a yellow coat regardless of the genes it carries on the other two genes. Only a dominant black allele at CBD103 will produce a black coat color in dogs possessing wild-type alleles at MC1R and Agouti. [8]
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The disease in dogs can affect the lungs and skin, but more commonly the eye and central nervous system. [20] Ringworm is a fungal skin disease that in dogs is caused by Microsporum canis (70%), Microsporum gypseum (20%), and Trichophyton mentagrophytes (10%). Typical signs in dogs include hair loss and scaly skin. [21]
Cropped ear: Shaped by cutting; see cropping. Drop ear: An ear that folds and droops close to the head, such as the little known Blue Lacy. Also called a pendant ear. Natural: Like a wolf's. Prick ear: Erect and pointed; also called pricked or erect. Rose ear: A very small drop ear that folds back; as in the greyhound or bulldog.