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The primary difference is the benefit that Fischer Projections provide in depicting the orientation of substituents with the vertical and horizontal lines. Considering that orientation of these molecules is already known, it may be properly depicted with wedges and dashes if needed.
As is depicted in a Fischer projection of D-threose, the adjacent substituents will have a syn orientation in the isomer referred to as "threo", and are anti in the isomer referred to as "erythro". [3] [4] Fischer projections depicting the two enantiomers of threose
Examples of absolute configuration of some carbohydrates and amino acids according to Fischer projection (D/L system) and Cahn–Ingold–Prelog priority rules (R/S system) The R/S system is an important nomenclature system for denoting enantiomers.
Nonetheless, the Fischer projection is a simple way of depicting multiple sequential stereocenters that does not require or imply any knowledge of actual conformation. A Fischer projection will restrict a 3-D molecule to 2-D, and therefore, there are limitations to changing the configuration of the chiral centers.
Hermann Emil Louis Fischer FRS FRSE FCS (German pronunciation: [ˈeːmiːl ˈfɪʃɐ] ⓘ; 9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He also ...
English: Fischer projection of D-Glyceraldehyde ((R)-2,3-Dihydroxypropanale) ... Add a one-line explanation of what this file represents. Items portrayed in this file
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The skeletal formula of the antidepressant drug escitalopram, featuring skeletal representations of heteroatoms, a triple bond, phenyl groups and stereochemistry. The skeletal formula, line-angle formula, bond-line formula or shorthand formula of an organic compound is a type of molecular structural formula that serves as a shorthand representation of a molecule's bonding and some details of ...