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Glucose 6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with glucose 6-phosphatase-α. Within the glucose 6-phosphatase-β enzyme, sequence alignments predict that its active site contains His167, His114, and Arg79.
Glucose-6-phosphatase, catalytic subunit (glucose 6-phosphatase alpha) is an enzyme that in humans is encoded by the G6PC gene. [ 5 ] [ 6 ] Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate.
This gene encodes the catalytic subunit of glucose 6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose 6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. [5]
[5] [6] [7] It consists of three subunits, each of which are vital components of the multi-enzyme Glucose-6-Phosphatase Complex (G6Pase). This important enzyme complex is located within the membrane of the endoplasmic reticulum, and catalyzes the terminal reactions in both glycogenolysis and gluconeogenesis. [8]
14378 Ensembl ENSG00000278373 ENSG00000152254 ENSMUSG00000005232 UniProt Q9NQR9 Q9Z186 RefSeq (mRNA) NM_001081686 NM_021176 NM_001289856 NM_001289857 NM_021331 RefSeq (protein) NP_001075155 NP_066999 NP_001276785 NP_001276786 NP_067306 Location (UCSC) Chr 2: 168.9 – 168.91 Mb Chr 2: 69.04 – 69.06 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glucose-6-phosphatase 2 is an enzyme ...
English: glucose-6-phosphatase system: in the end of the gluconeogenesis glc-6-p is transported into the ER (G6PT = T1) and dephosphorylated (G6Pase). Glucose is transported out of the cell passing two glucose-transporters (GLUT7 = T3 and GLUT2). Inorg. Phosphate is transported back to the cytosol by the T2 transporter
The HK1 gene spans approximately 131 kb and consists of 25 exons. Alternative splicing of its 5’ exons produces different transcripts in different cell types: exons 1-5 and exon 8 (exons T1-6) are testis-specific exons; exon 6, located approximately 15 kb downstream of the testis-specific exons, is the erythroid-specific exon (exon R); and exon 7, located approximately 2.85 kb downstream of ...
A hexokinase is an enzyme that irreversibly phosphorylates hexoses (six-carbon sugars), forming hexose phosphate. In most organisms, glucose is the most important substrate for hexokinases, and glucose-6-phosphate is the most important product. Hexokinase possesses the ability to transfer an inorganic phosphate group from ATP to a substrate.