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The Scatchard equation is an equation used in molecular biology to calculate the affinity and number of binding sites of a receptor for a ligand. [1] It is named after the American chemist George Scatchard.
This can be seen on the Lineweaver–Burk plot as an increased intercept on the ordinate with no change in slope. Substrate affinity increases with uncompetitive inhibition, or lowers the apparent value of . Graphically uncompetitive inhibition can be identified in the plot parallel lines for the different concentrations of inhibitor..
The line with equation ax + by + c = 0 has slope -a/b, so any line perpendicular to it will have slope b/a (the negative reciprocal). Let (m, n) be the point of intersection of the line ax + by + c = 0 and the line perpendicular to it which passes through the point (x 0, y 0). The line through these two points is perpendicular to the original ...
In differential geometry, the radius of curvature, R, is the reciprocal of the curvature. For a curve, it equals the radius of the circular arc which best approximates the curve at that point. For surfaces, the radius of curvature is the radius of a circle that best fits a normal section or combinations thereof. [1] [2] [3]
A slope greater than one thus indicates positively cooperative binding between the receptor and the ligand, while a slope less than one indicates negatively cooperative binding. Transformations of equations into linear forms such as this were very useful before the widespread use of computers, as they allowed researchers to determine parameters ...
S = slope, θ = angle of slope (inclination). The velocity on the flat terrain is 5 km / h, the maximum speed of 6 km / h is achieved roughly at -2.86°. [5] On flat terrain this formula works out to 5 km/h. For off-path travel, this value should be multiplied by 3/5, for horseback by 5/4. [1]
The above procedure now is reversed to find the form of the function F(x) using its (assumed) known log–log plot. To find the function F, pick some fixed point (x 0, F 0), where F 0 is shorthand for F(x 0), somewhere on the straight line in the above graph, and further some other arbitrary point (x 1, F 1) on the same graph.
Problem 57 of the Rhind papyrus, a thousand years earlier, defines the seqt or seked as the ratio of the run to the rise of a slope, i.e. the reciprocal of gradients as measured today. The slopes and angles were measured using a sighting rod that the Greeks called a dioptra , the forerunner of the Arabic alidade .