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  2. Cervical lymph nodes - Wikipedia

    en.wikipedia.org/wiki/Cervical_lymph_nodes

    The classification of the cervical lymph nodes is generally attributed to Henri Rouvière in his 1932 publication "Anatomie des Lymphatiques de l'Homme" [6] [7] Rouviere described the cervical lymph nodes as a collar which surrounded the upper aerodigestive tract, consisting of submental, facial, submandibular, parotid, mastoid, occipital and retropharyngeal nodes, together with two chains ...

  3. LINE1 - Wikipedia

    en.wikipedia.org/wiki/LINE1

    L1 hypomethylation of colon tumor samples is correlated with cancer stage progression. [ 20 ] [ 21 ] Furthermore, less invasive blood assays for L1 copy number or methylation levels are indicative of breast or bladder cancer progression and may serve as methods for early detection.

  4. Immune checkpoint - Wikipedia

    en.wikipedia.org/wiki/Immune_checkpoint

    Cancer Therapy by Inhibition of Negative Immune Regulation (CTLA4, PD1) A2AR & A2BR: The Adenosine A2A receptor is regarded as an important checkpoint in cancer therapy because adenosine in the immune microenvironment, leading to the activation of the A2a receptor, is negative immune feedback loop and the tumor microenvironment has relatively high concentrations of adenosine. [27]

  5. DAHANCA - Wikipedia

    en.wikipedia.org/wiki/DAHANCA

    DAHANCA 8 (1998-2003, 70 pts) - Vineralbine and 5-FU in advanced head and neck cancer (phase 2). DAHANCA 9 (2000–06, 71 pts) - Randomized study of hyperfractionated accelerated vs accelerated radiotherapy in node-negative head and neck carcinoma. DAHANCA 10 (2002-2006, 522 pts) - Randomized study of the role of EPO in low-Hb patients

  6. PD-1 and PD-L1 inhibitors - Wikipedia

    en.wikipedia.org/wiki/PD-1_and_PD-L1_inhibitors

    In the cancer disease state, the interaction of PD-L1 on the tumor cells with PD-1 on a T-cell reduces T-cell function signals to prevent the immune system from attacking the tumor cells. [9] Use of an inhibitor that blocks the interaction of PD-L1 with the PD-1 receptor can prevent the cancer from evading the immune system in this way. [ 9 ]

  7. Sentinel lymph node - Wikipedia

    en.wikipedia.org/wiki/Sentinel_lymph_node

    The technique of sentinel node radiolocalization was co-founded by James C. Alex, MD, FACS and David N. Krag MD (University of Vermont Medical Center) and they were the first ones to pioneer this method for the use of cutaneous melanoma, breast cancer, head and neck cancer and Merkel cell carcinoma. Confirmative trials followed soon after. [25]

  8. Head and neck cancer - Wikipedia

    en.wikipedia.org/wiki/Head_and_neck_cancer

    Globally, head and neck cancer accounts for 650,000 new cases of cancer and 330,000 deaths annually on average. In 2018, it was the seventh most common cancer worldwide, with 890,000 new cases documented and 450,000 people dying from the disease. [12] The risk of developing head and neck cancer increases with age, especially after 50 years.

  9. Clinical endpoint - Wikipedia

    en.wikipedia.org/wiki/Clinical_endpoint

    The response rate is the percentage of patients on whom a therapy has some defined effect; for example, the cancer shrinks or disappears after treatment. [ 9 ] When used as a clinical endpoint for trials of cancer treatments, this is often called the objective response rate (ORR).

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