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Intravitreal injection is the method of administration of drugs into the eye by injection with a fine needle. The medication will be directly applied into the vitreous humor . [ 1 ] It is used to treat various eye diseases, such as age-related macular degeneration (AMD) , diabetic retinopathy , and infections inside the eye such as ...
Intravitreal administration is a route of administration of a drug, or other substance, in which the substance is delivered into the vitreous humor of the eye. "Intravitreal" literally means "inside an eye". Intravitreal injections were first introduced in 1911 when Ohm gave an injection of air into the vitreous humor to repair a detached retina.
Here, 2% xylocaine is introduced into the muscle cone behind the eyeball. The injection is usually given through the inferior fornix of the skin of the outer part of the lower lid when the eye is in primary gaze. The ciliary nerves, ciliary ganglion, oculomotor nerve and abducens nerve are anesthetized in retrobulbar block. [2]
Ranibizumab is a smaller fragment, Fab fragment, of the parent bevacizumab molecule specifically designed for eye injections. [82] Other approved antiangiogenic drugs for the treatment of neovascular AMD include pegaptanib [ 83 ] and aflibercept .
An intracameral injection is usually of an antibiotic into the anterior chamber of the eyeball to prevent endophthalmitis caused by an infection of the eye that can occur after cataract surgery. The Food and Drug Administration (FDA) has not approved antibiotics for this use and it is considered 'off-label'.
Figure 1.0 - Basic anatomical features of the human eye. Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]
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