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Interest in the bacteria waned, however, when an American study published in 1954 failed to observe the bacteria in 1180 stomach biopsies. [200] Interest in understanding the role of bacteria in stomach diseases was rekindled in the 1970s, with the visualization of bacteria in the stomachs of people with gastric ulcers. [201]
J. Allende publishes a book describing the treatment of gastric ulcers with penicillin. [2] 1953 Dintzis and Hastings are able to stop urease production in mice with antibiotics, suggesting a relationship between urease and a bacterial infection. [19] 1954 Palmer publishes a study which finds no bacteria in the human stomach.
The primary goal of the treatment is not only temporary relief of symptoms but also total elimination of H. pylori infection. Patients with active duodenal or gastric ulcers and those with a prior ulcer history should be tested for H. pylori. Appropriate therapy should be given for eradication.
Another common condition is gastric ulceration, peptic ulcers. Ulceration erodes the gastric mucosa, which protects the tissue of the stomach from the stomach acids. Peptic ulcers are most commonly caused by a bacterial Helicobacter pylori infection. [5] Epstein–Barr virus infection is another factor to induce gastric cancer. [6] [7]
Gastritis is the inflammation of the lining of the stomach. [1] It may occur as a short episode or may be of a long duration. [1] There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia). [1]
It can be caused by persistent infection with Helicobacter pylori, or can be autoimmune in origin. Those with autoimmune atrophic gastritis ( Type A gastritis ) are statistically more likely to develop gastric carcinoma (a form of stomach cancer ), Hashimoto's thyroiditis , and achlorhydria .
Treatment Immediate surgery A perforated ulcer is a condition in which an untreated ulcer has burned through the mucosal wall in a segment of the gastrointestinal tract (e.g., the stomach or colon ) allowing gastric contents to leak into the abdominal cavity .
Many stomach diseases are associated with infections. In the past it was widely but incorrectly believed that the highly acidic environment of the stomach would keep the stomach immune from infection. Many studies have indicated that most cases of stomach ulcers, gastritis, and stomach cancer are caused by Helicobacter pylori infection.