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Acetohexamide binds to an ATP-sensitive K + (K ATP) channel on the cell membrane of pancreatic beta cells.This inhibits the outflux of potassium, which causes the membrane potential to become more positive.
Its Tmax (or time to reach maximum drug concentration in plasma) occurs 1 to 4 hours after oral administration. The mean serum half-life of sulfamethoxazole is 10 hours. [8] However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute.
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine, as the besilate, a dihydropyridine calcium channel blocker, and olmesartan medoxomil, an angiotensin II receptor blocker.
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Trimethadione (Tridione) is an oxazolidinedione anticonvulsant.It is most commonly used to treat epileptic conditions that are resistant to other treatments.. It is primarily effective in treating absence seizures, but can also be used in refractory temporal lobe epilepsy.
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