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5α-Reductase inhibitors (5 ... and prevention of prostate cancer. While the 5-ARI finasteride ... Cranell Alpha, Pantostin) is a topical 5-ARI used to ...
This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase.This enzyme is responsible for the conversion of the androgen hormone testosterone into the more potent dihydrotestosterone (DHT) and is essential for the production of neurosteroids like allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol from ...
5α-Reductase type 1 inactivated male mice have reduced bone mass and forelimb muscle grip strength, which has been proposed to be due to lack of 5α-reductase type 1 expression in bone and muscle. [29] In 5 alpha reductase type 2 deficient males, the type 1 isoenzyme is thought to be responsible for their virilization at puberty. [6]
5-alpha reductase blockers reduce DHT levels, slowing down, stopping, or reversing the effects of male pattern baldness. ... Finasteride has been shown to lower the overall risk of prostate cancer ...
However, 5α-reductase inhibitors have been found to increase the risk of developing certain rare but aggressive forms of prostate cancer (27% risk increase), although not all studies have observed this. [35] No impact of 5-α-reductase inhibitor on survival has been found in people with prostate cancer. [35]
This finding prompted the FDA to release a safety announcement regarding 5-alpha reductase inhibitors (including finasteride), noting the potential for an increased risk of high-grade prostate cancer.
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