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  2. Monkey Drug Trials - Wikipedia

    en.wikipedia.org/wiki/Monkey_Drug_Trials

    The Monkey Drug Trials experiment was influenced by preceding research discussing related topics. [2] Six notable research publications may be highlighted: “Factors regulating oral consumption of an opioid (etonitazene) by morphine-addicted rats”; [3] “Experimental morphine addiction: Method for automatic intravenous injections in unrestrained rats.”; [4] ”Morphine self ...

  3. Conditioned avoidance response test - Wikipedia

    en.wikipedia.org/wiki/Conditioned_avoidance...

    The test can detect antipsychotic-like activity both in the case of dopamine D 2 receptor antagonists and in the case of drugs lacking D 2 receptor antagonism. [1] [2] [6] The occupancy of the D 2 receptor by antagonists of this receptor required to inhibit the CAR is around 65 to 80%, which is similar to the occupancy at which therapeutic antipsychotic effects occur in humans with these drugs.

  4. Animal efficacy rule - Wikipedia

    en.wikipedia.org/wiki/Animal_Efficacy_Rule

    The FDA animal efficacy rule (also known as animal rule) applies to development and testing of drugs and biologicals to reduce or prevent serious or life-threatening conditions caused by exposure to lethal or permanently disabling toxic agents (chemical, biological, radiological, or nuclear substances), where human efficacy trials are not feasible or ethical. [1]

  5. Animal products in pharmaceuticals - Wikipedia

    en.wikipedia.org/wiki/Animal_products_in...

    A separate issue is the use of testing on animals as a means of initial testing during drug development, or actual production. [40] Guiding principles for more ethical use of animals in testing are the Three Rs first described by Russell and Burch in 1959. [41] These principles are now followed in many testing establishments worldwide.

  6. Animal testing - Wikipedia

    en.wikipedia.org/wiki/Animal_testing

    Animal testing, science, medicine, animal welfare, animal rights, ethics Animal testing , also known as animal experimentation , animal research , and in vivo testing , is the use of non-human animals , such as model organisms , in experiments that seek to control the variables that affect the behavior or biological system under study.

  7. 65 Unsettling Medical Facts That Are Not For The Faint Of Heart

    www.aol.com/lifestyle/65-unsettling-medical...

    Image credits: Ludwig_Vista2 #7. Endometriosis (tissue from the womb) is not cancer. But it can send out cells that spread through your internal organs and grow, stick your guts together or block ...