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Intrauterine hypoxia (also known as fetal hypoxia) occurs when the fetus is deprived of an adequate supply of oxygen. It may be due to a variety of reasons such as prolapse or occlusion of the umbilical cord , placental infarction , maternal diabetes (prepregnancy or gestational diabetes ) [ 1 ] and maternal smoking .
A normal nonstress test will show a baseline fetal heart rate between 110 and 160 beats per minute with moderate variability (5- to 25-interbeat variability) and 2 qualifying accelerations in 20 minutes with no decelerations. "Reactive" is defined as the presence of two or more fetal heart rate accelerations within a 20-minute period. Each ...
The fetal circulation is composed of the placenta, umbilical blood vessels encapsulated by the umbilical cord, heart and systemic blood vessels. A major difference between the fetal circulation and postnatal circulation is that the lungs are not used during the fetal stage resulting in the presence of shunts to move oxygenated blood and ...
It is characterized by changes in fetal movement, growth, heart rate, and presence of meconium stained fluid. [ 4 ] Risk factors for fetal distress/non-reassuring fetal status include anemia , restriction of fetal growth , maternal hypertension or cardiovascular disease, low amniotic fluid or meconium in the amniotic fluid, or a post-term ...
The heart rate increases, but generally not above 100 beats/ minute. Total systematic vascular resistance decreases by 20% secondary to the vasodilatory effect of progesterone. Overall, the systolic and diastolic blood pressure drops 10–15 mm Hg in the first trimester and then returns to baseline in the second half of pregnancy. [ 6 ]
A Zigzag pattern of fetal heart rate (FHR) is defined as FHR baseline amplitude changes of more than 25 beats per minute (bpm) with a minimum duration of 2 minutes and maximum of 30 minutes. [19] However, according to another study, even a >1 min duration of the zigzag pattern is associated with an increased risk of adverse neonatal outcomes. [21]
Histopathology of placenta with increased syncytial knotting of chorionic villi, with two knots pointed out. The following characteristics of placentas have been said to be associated with placental insufficiency, however all of them occur in normal healthy placentas and full term healthy births, so none of them can be used to accurately diagnose placental insufficiency: [citation needed]
When the baby is born, the lungs are needed for oxygen transfer and need high blood flow which is encouraged by low PVR. The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal circulation. [2] The newborn is therefore born with elevated PVR, which leads to pulmonary hypertension.