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Tetracyclines are a group of broad-spectrum antibiotic compounds that have a common basic structure and are either isolated directly from several species of Streptomyces bacteria or produced semi-synthetically from those isolated compounds. [1] Tetracycline molecules comprise a linear fused tetracyclic nucleus (rings designated A, B, C and D ...
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Some tricyclic compounds having three fused and one tethered ring (connected to main nucleus by a single bond) can also classified as tetracyclic, for example, ciclazindol. [1] Tetracyclic compounds have various pharmaceutical uses, such as: tetracycline antibiotics. Doxycycline; Tigecycline; Omadacycline; Eravacycline; tetracyclic ...
Tetracycline hydrochloride is available as yellow crystalline powder. Since tetracycline is absorbed into bone, it is used as a marker of bone growth for biopsies in humans. Tetracycline labeling is used to determine the amount of bone growth within a certain period of time, usually a period around 21 days.
The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic . Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.
Tetracene is a molecular organic semiconductor, used in organic field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs). Tetracene can be used as a gain medium in dye lasers as a sensitiser in chemoluminescence. Napthacene is the main component of the tetracycline class of antibiotics.
Oxytetracycline, like other tetracyclines, is used to treat many infections, both common and rare.Its better absorption profile makes it preferable to tetracycline for moderately severe acne at a dosage of 250–500 mg four times a day for usually six to eight weeks at a time, but alternatives should be sought if no improvement occurs by three months.
The overall structure of TetR can be broken down into two DNA-binding domains (one per monomer) and a regulatory core, which is responsible for tetracycline recognition and dimerization. TetR dimerizes by making hydrophobic contacts within the regulatory core. There is a binding cavity for tetracycline in the outer helices of the regulatory domain.