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DDIT4 acts as a negative regulator of mTOR, [7] a serine/threonine kinase that regulates a variety of cellular functions such as growth, proliferation and autophagy. [8] In particular, upregulation of HIF-1 in response to hypoxia upregulates DDIT4, [5] leading to activation of Tsc1/2 via 14–3–3 shuttling [9] and subsequent downregulation of mTOR via Rheb. [10]
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
10912 23882 Ensembl ENSG00000130222 ENSMUSG00000021453 UniProt O95257 Q9Z111 Q9R0S0 RefSeq (mRNA) NM_006705 NM_011817 RefSeq (protein) NP_006696 NP_035947 Location (UCSC) Chr 9: 89.61 – 89.61 Mb Chr 13: 52 – 52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on ...
WNT1-inducible-signaling pathway protein 1 (WISP-1), [5] is a member of the CCN protein family and should correctly be referred to as CCN4 as suggested by the International CCN Society. [6] It is a matricellular protein that in humans is encoded by the WISP1 gene .
Protein phosphatase 1 regulatory subunit 15A, also known as growth arrest and DNA damage-inducible protein (GADD34), is a protein that in humans is encoded by the PPP1R15A gene. [ 5 ] [ 6 ] [ 7 ] The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically ...
DNA gene structure of a eukaryote. In genetics, a silencer is a DNA sequence capable of binding transcription regulation factors, called repressors.DNA contains genes and provides the template to produce messenger RNA (mRNA).