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The megakaryocyte develops through the following lineage: CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte. Megakaryocytes are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the liver, kidney, spleen, and bone marrow.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
CFU-GEMM is a colony forming unit that generates myeloid cells.CFU-GEMM cells are the oligopotential progenitor cells [1] [2] for myeloid cells; they are thus also called common myeloid progenitor cells or myeloid stem cells.
It is a ratio of the size (i.e., volume) of the nucleus of a cell to the size of the cytoplasm of that cell. [1] The N:C ratio indicates the maturity of a cell, because as a cell matures the size of its nucleus generally decreases.
Megakaryocyte: Platelets if considered distinct cells, currently there's debate on the subject. Monocyte (white blood cell) Connective tissue macrophage (various types) Epidermal Langerhans cell: Osteoclast: in bone Dendritic cell: Microglial cell: central nervous system: Neutrophil granulocyte: myeloblast, promyelocyte, myelocyte, metamyelocyte
Promegakaryocyte. A promegakaryocyte is a precursor cell for a megakaryocyte, the development of which proceeds as follows: [1]. CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets .
Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. [ 2 ] [ 3 ] Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor cells.