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A high-dose vaccine (Fluzone High-Dose) four times the strength of standard flu vaccine was approved by the FDA in 2009. [22] [23] [24] This vaccine is intended for people 65 and over, who typically have weakened immune response due to normal aging. The vaccine produces a greater immune response than standard vaccine.
Available evidence indicates that vaccinating the elderly with the high-dose vaccine leads to a stronger immune response against influenza than the regular-dose vaccine. [130] [131] [132] A flu vaccine containing an adjuvant was approved by the US Food and Drug Administration (FDA) in November 2015, for use by adults aged 65 years of age and ...
Some flu vaccines may also be potentially more effective than others in certain age groups. For example, the United States Centers for Disease Control and Prevention (CDC) preferentially recommended quadrivalent vaccines like high-dose flu vaccines, recombinant influenza vaccines, and adjuvanted flu vaccines to people of 65 or above. [17]
For more than a decade, flu shots in the U.S. also protected against a fourth strain of influenza B, but that strain hasn’t circulated since March 2020, so the Food and Drug Administration’s ...
The CDC recommends three flu vaccines for people 65 and older: the Fluzone High-Dose inactivated flu vaccine, the Flublok recombinant flu vaccine and the Fluad adjuvanted inactivated flu vaccine.
In September 2009, a live attenuated influenza vaccine for the novel H1N1 influenza virus was approved. [28] In 2011, the vaccine was approved by the European Medicines Agency (EMA) for use in the European Union under the brand name Fluenz. [5] [32] AstraZeneca acquired MedImmune and retired the MedImmune name.
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