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Infliximab is a chimeric monoclonal antibody biologic. It seems to work by binding to and neutralizing TNF-α, preventing it from interacting with its receptors on the cell. [23] TNF-α is a chemical messenger and a key part of the autoimmune reaction. Infliximab was originally developed in mice as a mouse antibody.
The anti-TNF-α monoclonal antibody infliximab is a major biological therapy for inflammatory bowel disease. Biological therapy, the use of medications called biopharmaceuticals or biologics that are tailored to specifically target an immune or genetic mediator of disease, plays a major role in the treatment of inflammatory bowel disease. [1]
Classes of biologics typically used for psoriatic arthritis include TNF inhibitors, anti-IL17-A antibodies, IL-23 antibodies, and those that act on both IL-12 and IL-23. [7] Biologics can treat inflammatory bowel disease. Classes of biologics typically used for inflammatory bowel disease include TNF inhibitors, and anti-CD28 antibodies. [6]
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Known as tumor necrosis factor-alpha, or TNF-alpha, antagonists, these standard drugs include the popular Remicade from Janssen. A small section of the total Crohn's Disease) patient population is ...
A TNF-α (tumor necrosis factor-alpha) binding protein is a monoclonal antibody or a circulating receptor such as infliximab (Remicade), etanercept (Enbrel), or adalimumab (Humira) that binds to TNF-α, preventing it from inducing the synthesis of IL-1 and IL-6 and the adhesion of lymphocyte-activating molecules.
Monoclonal antibodies used for autoimmune diseases include infliximab and adalimumab, which are effective in rheumatoid arthritis, Crohn's disease, ulcerative colitis and ankylosing spondylitis by their ability to bind to and inhibit TNF-α. [46]
decoy TNF receptor: bDMARD filgotinib: Janus kinase (JAK) inhibitor tsDMARD golimumab: TNF inhibitor: bDMARD gold salts (sodium aurothiomalate, auranofin) (seldom used today) unknown csDMARD hydroxychloroquine (anti-malarial) TNF-alpha, induce apoptosis of inflammatory cells and decrease chemotaxis: csDMARD infliximab: TNF inhibitor: bDMARD ...