Ads
related to: hiv 1 5' utr region 10 il- Patient Assistance Info
Discover If You Are Eligible To
Save On An HIV-1 Treatment Option.
- Download Patient Brochure
Find Resources With Important Info
About Treatment And Switching.
- HIV Real Patient Stories
Watch The Stories Of People Who
Share Their Treatment Experiences.
- Learn How Treatment Works
Visit The Patient Website To Learn
How An HIV-1 Treatment Works.
- Sign Up For More Info
Learn About An HIV Treatment Option
Sign Up To Receive Information.
- HIV Treatment FAQs
Find Answers To Frequently Asked
Questions About HIV And Medication.
- Patient Assistance Info
Search results
Results From The WOW.Com Content Network
The genome and proteins of HIV (human immunodeficiency virus) have been the subject of extensive research since the discovery of the virus in 1983. [1] [2] "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus (HTLV), which was known at the time to affect the human immune system and cause certain leukemias.
In HIV-1, the 5'UTR region has been characterized according to functional and structural differences into several sub-regions: TAR, or trans-activation response element, plays a critical role in transcriptional activation via its interaction with viral proteins.
The 5′ UTR begins at the transcription start site and ends one nucleotide (nt) before the initiation sequence (usually AUG) of the coding region. In prokaryotes, the length of the 5′ UTR tends to be 3–10 nucleotides long, while in eukaryotes it tends to be anywhere from 100 to several thousand nucleotides long. [4]
Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the 5' UTR can be translated into peptides. [1] The 5' UTR is upstream from the coding sequence. Within the 5' UTR is a sequence that is recognized by the ribosome which allows the ribosome to bind and initiate translation.
The HIV trans-activation response (TAR) element is an RNA element which is known to be required for the trans-activation of the viral promoter and for virus replication. The TAR hairpin is a dynamic structure [1] that acts as a binding site for the Tat protein, and this interaction stimulates the activity of the long terminal repeat promoter.
The human IL-15 gene comprises nine exons (1–8 and 4A) and eight introns, four of which (exons 5 through 8) code for the mature protein. Figure 2. The originally identified isoform, with long signal peptide of 48 amino acids (IL-15 LSP) consisted of a 316 bp 5'-untraslated region (UTR), 486 bp coding sequence and on the C-terminus 400 bp 3 ...
Ads
related to: hiv 1 5' utr region 10 il