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Symptoms include brittle hair, mild mental retardation and nail dysplasia.The syndrome was first observed in Sabinas, a small community in northern Mexico.. The principal biochemical features of the illness are reduced hair cystine levels, increased copper/zinc ratio, and presence of arginosuccinic acid in the blood and urine.
8 Autoimmune Diseases That Cause Hair Loss. This article was reviewed by Knox Beasley, MD.. You might associate autoimmune conditions with symptoms like skin disease, chronic pain, and fatigue.
Nail abnormalities in ED often manifest as dysplastic or poorly formed nails. Affected individuals may have thin, brittle, or ridged nails that are prone to splitting and breaking. In severe cases, nails may be entirely absent or exhibit atypical growth patterns, including spoon-like (koilonychia) or thickened (pachyonychia) appearances. [1] [2]
In about 70 percent of cases, carriers of hypohidrotic ectodermal dysplasia experience some features of the condition. These signs and symptoms are usually mild and include a few missing or abnormal teeth, sparse hair, and some problems with sweat gland function. Some carriers, however, have more severe features of this disorder.
The signs and symptoms of Graves' disease generally result from the direct and indirect effects of hyperthyroidism, although they can also be caused by other thyroidal conditions, such as Graves' ophthalmopathy, goitre and pretibial myxedema. These clinical manifestations can involve virtually every system in the body.
Symptoms include lack of sweat glands, thin hair, brittle nails, mottled skin, and lack of fingerprints. [6] It is also characterized by a widespread, early-onset reticulate hyperpigmentation. [ 7 ] Those affected may also have adermatoglyphia , abnormal epithelial differentiation, palmoplantar hyperkeratosis of the palms and soles, acral ...