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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
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One study suggests that adding calcium and vitamin D supplementation to a lower-calorie diet may increase fat loss in people who typically consume low levels of calcium compared to people who only ...
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Approval was granted on 7 February 2007, [42] and Alli became the first weight loss drug officially sanctioned by the U.S. government for over-the-counter use. [43] Consumer advocacy organization Public Citizen opposed over-the-counter approval for orlistat. [14] Alli became available in the U.S. in June 2007.
Mild calorie restriction may be beneficial for pregnant women to reduce weight gain (without weight loss) and reduce perinatal risks for both the mother and child. [11] [12] For overweight or obese individuals, calorie restriction may improve health through weight loss, although a gradual weight regain of 1–2 kg (2.2–4.4 lb) per year may occur.