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The miRBase registry provides a centralised system for assigning new names to microRNA genes. [6] miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003. [7] According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims: [1] To provide a consistent naming system for microRNAs
miRBase: the microRNA database; PolymiRTS: a database of DNA variations in putative microRNA target sites; PolyQ: database of polyglutamine repeats in disease and non-disease associated proteins; Rfam: a database of RNA families; IRESbase: A comprehensive database of experimentally validated internal ribosome entry sites. [14]
This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets. MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting messenger RNAs.
The American Economic Association's electronic database, the world's foremost source of references to economic literature. Subscription Produced by the American Economic Association. [52] Available from EBSCOhost, ProQuest, OVID, and AEA. [53] EMBASE: Biomedicine, pharmacology: Biomedical database with a strong focus on drug and pharmaceutical ...
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Many mammalian genomes encode four closely related miR-29 precursors that are transcribed in two transcriptional units. For example, human miR-29a and miR-29b-1 are processed from an intron of a long non-coding transcript pri-miRNA (lnc-pri-miRNA) LOC646329 from chromosome 7. miR-29b-2 (identical in sequence to miR-29b-1) and miR-29c are co-transcribed from chromosome 1.
In molecular biology miR-132 microRNA is a short non-coding RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms, generally reducing protein levels through the cleavage of mRNAs or the repression of their translation.
As miR recognition elements are typically found in the 3' UTR of the target gene mRNA, bioinformatics alone can identify putative miR-92 targets using resources such as miRGen database. In one report, miRanda software found 300 different genes that have putative miR-92a binding sites conserved among Homo sapiens, Mus musculus, and Rattus ...