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Menopause is the permanent cessation of menstruation resulting from loss of ovarian follicular activity, defined as beginning twelve months after the final natural menstrual cycle. This twelve month time point divides menopause into early and late transition periods known as 'perimenopause' and 'postmenopause'. [4]
Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of the reproductive stage for the female human. [1] [6] [7] It typically occurs between the ages of 45 and 55, although the exact timing can vary. [8]
Average number of moderate-to-severe hot flashes per week with placebo and different doses of oral estradiol in menopausal women [40] [41]. Estradiol is used in menopausal hormone therapy to prevent and treat moderate to severe menopausal symptoms such as hot flashes, vaginal dryness and atrophy, and osteoporosis (bone loss). [11]
The Australian Menopause Society has similarly stated that there is no evidence that bioidentical hormones administered using lozenges are any safer than their approved counterparts. [53] [54] The International Menopause Society has stated "There are no medical or scientific reasons to recommend unregistered 'bioidentical hormones'. The ...
After menopause the vaginal epithelium changes and becomes a few layers thick. [18] Many of the signs and symptoms that accompany menopause occur in atrophic vaginitis. [3] The earliest symptoms of atrophic vaginitis may be decreased vaginal lubrication, while other symptoms may appear later. [14] Genitourinary symptoms include dryness [3] [19 ...
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