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Evolution of a 4 mm nodular melanoma. Nodular melanoma (NM) is the most aggressive form of melanoma. [1] It tends to grow more rapidly in thickness (vertically penetrate the skin) than in diameter compared to other melanoma subtypes. [2] Instead of arising from a pre-existing mole, it may appear in a spot where a lesion did not previously exist.
Melanoma is the most dangerous type of skin cancer. [2] Globally, in 2012, it newly occurred in 232,000 people. [2] In 2015, 3.1 million people had active disease, which resulted in 59,800 deaths. [5] [6] Australia and New Zealand have the highest rates of melanoma in the world. [2]
In recognition of his contribution, the depth of invasion of melanoma is referred to by the eponym Breslow's depth. Subsequent studies confirmed and refined the role of depth of invasion in the prognosis of malignant melanoma. [2] [3] Currently, Breslow's depth is included in the AJCC staging guidelines for melanoma as a major prognostic factor.
However, a melanocytic nevus is benign, and melanoma is malignant. Most melanocytic nevi never evolve into a cancer, with the lifetime risk for an individual nevus being 1 in 3000 for men and 1 in 11 000 for women. [5] Moreover, dermatologists have a standardized system for determining whether a skin lesion is suspicious for malignant melanoma.
Murphy, George F. "Case 12: Melanocytic tumor of uncertain malignant potential (MELTUMP)". In Artur Zembowicz (ed.). Cases in Dermatopathology: Common Problems in Diagnosis of Pigmented Lesions. Los Gatos, California: Knowledge Books and Software. pp. 73– 80. ISBN 1-74162-088-0
Polypoid melanoma is a rare cutaneous condition, a virulent variant of nodular melanoma. [ 1 ] : 696 Polypoid melanoma is a subtype of nodular melanoma , the most aggressive form of melanoma (a skin cancer).
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