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MGUS is a common, age-related medical condition characterized by an accumulation of bone marrow plasma cells derived from a single abnormal clone. Patients may be diagnosed with MGUS if they fulfill the following four criteria: [7] A monoclonal paraprotein band less than 30 g/L (< 3g/dL); Plasma cells less than 10% on bone marrow examination;
Monoclonal gammopathy, also known as paraproteinemia, is the presence of excessive amounts of myeloma protein or monoclonal gamma globulin in the blood. It is usually due to an underlying immunoproliferative disorder or hematologic neoplasms, especially multiple myeloma. It is sometimes considered equivalent to plasma cell dyscrasia.
[3] [4] Chronic pain is considered a syndrome because of the associated symptoms that develop in those experiencing this disorder. [5] Chronic pain affects approximately 20% of people worldwide and accounts for 15–20% of visits to a physician. [3] Pain can be categorized according to its location, cause, or the anatomical system which it affects.
In hematology, plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma ...
The most common type of heavy chain disease is the IgA type, known as αHCD. The most common type of αHCD is the gastrointestinal form (known as immunoproliferative small intestine disease or IPSID), but it has also been reported in the respiratory tract, and other areas of the body.
Cerebro-oculo-facio-skeletal syndrome: COLD Chronic obstructive lung disease: COPD Chronic obstructive pulmonary disease: COVID-19 Coronavirus disease 2019: CP Cerebral palsy: CP/CPPS: Chronic prostatitis/chronic pelvic pain syndrome: CPDD Calcium pyrophosphate deposition disease: CPM Central pontine myelinolysis: CPPS Chronic pelvic pain ...
The most common causes of polyclonal hypergammaglobulinaemia detected by electrophoresis are severe infection, chronic liver disease, rheumatoid arthritis, systemic lupus erythematosus and other connective tissue diseases. [citation needed] A narrow spike is suggestive of a monoclonal gammopathy, also known as a restricted band, or "M-spike".
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