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Weight gain [18] There has been a study that suggests antipsychotics are associated with possible cortical reconfiguration and gray matter loss, [19] but correlational data also suggests patients who consume antipsychotics, like people with schizophrenia, tend to engage in unhealthy habits like smoking which may exacerbate gray matter loss. [20]
People on typical antipsychotics tend to have a higher rate of extrapyramidal side effects while some atypicals are associated with considerable weight gain, diabetes, and risk of metabolic syndrome; this is most pronounced with olanzapine, while risperidone and quetiapine are also associated with weight gain. [9]
Maintenance therapy with antipsychotic drugs is clearly superior to placebo in preventing relapse but is associated with weight gain, movement disorders, and high dropout rates. [40] A 3-year trial following persons receiving maintenance therapy after an acute psychotic episode found that 33% obtained long-lasting symptom reduction, 13% ...
Estimation of serum sodium levels from weight gain and suggested interventions [28] Weight gained (% body mass) Estimated serum sodium (mmol/L) Suggested intervention 0-3 140 - 134 No direct intervention, monitoring: 3-5 133 - 130 Redirection from water sources 5-7 129–126 Oral NaCl and redirection 7–10 125–120
It has been associated with significant weight gain. [13] Quetiapine binds D 1, D 2 and D 3 and can bind D 4 at high concentrations. [2] It is used to treat the positive symptoms of schizophrenia, [13] bipolar disorder and depression. [1] Of the second generation antipsychotics, quetiapine may produce fewer parkinsonian side effects. [24]
Individuals may MUA antipsychotics for various reasons, including recreational purposes, self-medication, or attempting to alter their mental or emotional state.The most common forms of antipsychotic abuse may include non-prescribed use, which involves the use of antipsychotic medications without a valid legal prescription or the absence of medical supervision.
The drug is sometimes described as a typical antipsychotic, [5] and sometimes described as an atypical antipsychotic. [6] Chemically, molindone is an indole and is structurally distinct from many other antipsychotics. [2] Molindone was first described by 1966 [7] and was introduced for medical use in 1974. [8] It remains marketed only in the ...
Produces roughly as much weight gain as risperidone, less weight gain than clozapine, olanzapine and zotepine and more weight gain than ziprasidone, lurasidone, aripiprazole and asenapine. [22] As with many other atypical antipsychotics, this action is likely due to its actions at the H 1 histamine receptor and 5-HT 2C receptor .