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Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
As of June 2022, the company had a selection of over 100 generic drugs, [7] and by March 2023, over 350 drugs were available. [8] In December 2023, the company had over 2200 drugs available. The drugs are sold for a price equivalent to the company's cost plus 15% markup, a $5 pharmacy service fee, and a $5 shipping fee.
Sildenafil's brand name, Viagra, is widely recognized in popular culture, and the drug's association with treating erectile dysfunction has led to its recreational use. [33] The reasons behind such use include the belief that the drug increases libido, improves sexual performance, [ 33 ] or permanently increases penis size. [ 34 ]
When to Take Viagra: 30-60 Minutes Before Intimacy, Not Earlier. If you’re planning to have intimacy, it’s best to take your recommended dose of Viagra ahead of time.
Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.
Participants started off on 100 milligrams of sildenafil for three days before moving on to 200 milligrams for two days. The medication seemed to treat the condition and was well tolerated.
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