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For colorectal cancer and hepatic metastases, an average adult should be given an intra-arterial dosage of 0.1–0.6 mg/kg/day as a continuous infusion, continued until intolerable toxicity is reached (white blood cell count < 3,500/mm 3 or platelet count < 100,000/mm 3). [8]
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
The goal of nocturnal penile tumescence testing is to determine whether one can experience an erection while sleeping after reporting that they are unable to experience an erection while awake. On average, one has 3–5 episodes of NPT each night, and each episode lasts 30–60 minutes, although the duration is reduced with advanced age. [16]
If you haven’t been told a time, don’t panic. There’s no best time to take metformin, but you should aim to take it at the same time each day to avoid missing or doubling up on doses.
Sleep inversion may be a symptom of elevated blood ammonia levels [2] and is often an early symptom of hepatic encephalopathy. [3] Sleep inversion is a feature of African trypanosomiasis, after which the disease takes its common name, "African sleeping sickness"; [4] sleep-wake cycle disturbances are the most common indication that the disease has reached the stage where infection spreads into ...
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The information about using topical imiquimod cream (Aldara) is misleading - nearly all Mohs surgeons I know (> 20) do not use imiquimod cream and there is no reason why imiquimod cream is used over any other cream such as fluorouracil (Efudex or Carac) - I am concerned about this being a commercial endorsement.
Waking up earlier in the morning increases the response. [11]Shift work: nurses working on morning shifts with very early awakening (between 4:00–5:30 a.m.) had a greater and prolonged cortisol awakening response than those on the late day shift (between 6:00–9:00 a.m.) or the night shift (between 11:00 a.m.–2:00 p.m.). [12]