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Current evidence shows that aminoglycosides do retain activity against the majority of Gram-negative clinical bacterial isolates in many parts of the world. Still, the relatively frequent occurrence of nephrotoxicity and ototoxicity during aminoglycoside treatment makes physicians reluctant to use these compounds in everyday practice.
Odanacatib (INN; [1] codenamed MK-0822) is an investigational treatment for osteoporosis and bone metastasis. [2] It is an inhibitor of cathepsin K , [ 3 ] an enzyme involved in bone resorption . The drug was developed by Merck & Co.
Aminoglycosides — their use is extremely restricted due to risk of hearing loss and kidney damage. Amphotericin B — used for life-threatening fungal infections and primary amoebic meningoencephalitis; [3] its side effects are often severe or potentially fatal.
Senile osteoporosis has been recently recognized as a geriatric syndrome with a particular pathophysiology. There are different classification of osteoporosis: primary, in which bone loss is a result of aging and secondary, in which bone loss occurs from various clinical and lifestyle factors. [1]
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.
In general, treatment with cephalosporins results in induction of AmpC beta-lactamase. [2] Treatment with an aminoglycoside or carbapenem is usually indicated. Carbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity.
Image credits: Michael Buckner / Getty #3 Scott Disick. Boxes of Mounjaro, which is known for its weight loss effects, were found stacked in Scott Disick’s fridge on a past episode of The ...
Sisomicin is the most predictably active aminoglycoside against Gram-positive bacteria. [2] Like most other aminoglycosides, sisomicin is bactericidal for sensitive clinical isolates. The minimum bactericidal concentrations (MBC) have been found to be equivalent or very close to the minimum inhibitory concentrations (MIC). [ 3 ]