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2-Methylimidazole (1) may be prepared via the Debus-Radziszewski imidazole synthesis, or from ethylenediamine and acetic acid, followed by treatment with lime, then Raney nickel. 2-Methylimidazole is nitrated to give 2-methyl-4(5)-nitroimidazole (2), which is in turn alkylated with ethylene oxide or 2-chloroethanol to give metronidazole (3 ...
For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. [99] The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections."
Nearly 13,000 Amazon shoppers give it an average 4.6-star rating, many citing its effectiveness for arthritis specifically. ... Neutral, slightly cooling | Scent: The gel does not have a strong ...
The recommended strength solution contains 10% Povidone, with total iodine species equaling 10,000 ppm or 1% total titratable iodine. [4] It works by releasing iodine which results in the death of a range of microorganisms. [1] Povidone-iodine came into commercial use in 1955. [5] It is on the World Health Organization's List of Essential ...
Clotrimazole, sold under the brand name Lotrimin, among others, is an antifungal medication. [2] It is used to treat vaginal yeast infections, oral thrush, diaper rash, tinea versicolor, and types of ringworm including athlete's foot and jock itch. [2]
Of the original Thirteen Colonies, Pennsylvania is the only state that does not border the Atlantic Ocean. The boundaries of the state are the Mason–Dixon line (39°43' N) to the south, Twelve-Mile Circle on the Pennsylvania- Delaware border, the Delaware River to the east, 80°31' W to the west, and the 42° N to the north, except for a ...
[18] [62] In 2013, oral ketoconazole was withdrawn in the European Union and Australia, and strict restrictions were placed on the use of oral ketoconazole in the United States and Canada. [18] Oral ketoconazole is indicated for use in these countries when the indication is a severe or life-threatening systemic infection and alternatives are ...
Miconazole is partly absorbed in the intestinal tract when used orally, as with the oral gel, and possibly when used vaginally. [9] This can lead to increased concentrations of drugs that are metabolized by the liver enzymes CYP3A4 and CYP2C9, because miconazole inhibits these enzymes.