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Denham Harman (February 14, 1916 – November 25, 2014) was an American medical academic who latterly served as professor emeritus at the University of Nebraska Medical Center. [ 1 ] [ 2 ] [ 3 ] Harman is known as the " father of the free radical theory of aging ".
Denham Harman first proposed the free radical theory of aging in the 1950s, [5] and in the 1970s extended the idea to implicate mitochondrial production of ROS. [6] In some model organisms, such as yeast and Drosophila, there is evidence that reducing oxidative damage can extend lifespan. [7]
In the 1950s Denham Harman proposed the free radical theory of ageing, which he later expanded to the MFRTA. When studying the mutations in antioxidants, which remove ROS, results were inconsistent. However, it has been observed that overexpression of antioxidant enzymes in yeast, worms, flies and mice were shown to increase lifespan.
The idea that free radicals are toxic agents was first proposed by Rebeca Gerschman and colleagues in 1945, [19] but came to prominence in 1956, when Denham Harman proposed the free-radical theory of aging and even demonstrated that free radical reactions contribute to the degradation of biological systems. [20]
AGE was founded in 1970 by Denham Harman, MD, PhD, who is often known as the "father" of the "free-radical theory of aging". [2] [3] Harman's goal was to form a lay-scientific organization patterned after the American Heart Association to promote biomedical aging research. [3]
In 1968 it took the form and became known as the neuroendocrine theory of aging. [38] [39] [40] 1956 Denham Harman proposed the free-radical theory of aging and demonstrated that free radical reactions contribute to the degradation of biological systems. [41] The theory is based on the ideas of Rebeca Gerschman and her colleagues put forward in ...
How to slow aging. The “Essential 8,” based on guidance from the heart association: Eat better. Consume a diet with a variety of fruits and vegetables, whole grains, healthy protein sources ...
Mechanistic evidence was provided by Denham Harman's free radical theory of aging, created in the 1950s. This theory stated that organisms age over time due to the accumulation of damage from free radicals in the body. [4] It also showed that metabolic processes, specifically the mitochondria, are prominent producers of free radicals. [4]