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Some drugs need to be used with caution in patients with renal dysfunction. The use of nitrofurantoin is contraindicated in patients with an estimated GFR of less than 30 mL/min/1.73m 2 as drug accumulation can lead to increased side effects and impaired recovery of the urinary tract, increasing the risk of treatment failure. [29]
Common side effects include nausea, vomiting, rash, and diarrhea. [2] Severe allergic reactions and Clostridioides difficile infection may occasionally occur. [2] Its use in pregnancy is not recommended. [2] [19] It appears to be safe for use during breastfeeding as long as the baby is healthy. [19]
Hypoprothrombinaemia and bleeding are specific side effects. Haemolysis is reported. [19] [20] [21] It has also been reported to cause post kidney failure in children. [22] Like other antibiotics, ceftriaxone use can result in Clostridioides difficile-associated diarrhea ranging from mild diarrhea to fatal colitis. [18]
When given for short periods, linezolid is a relatively safe antibiotic. [12] It can be used in people of all ages and in people with liver disease or poor kidney function. [10] Common side effects with short-term use include headache, diarrhea, rash, and nausea. [10]
Possible side effects [4] Mechanism of action Aminoglycosides; Amikacin: Amikin: Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as ...
Children; A 1998 retrospective survey found that numerous side effects have been recorded in reference to the unapproved use of norfloxacin in the pediatric population. [24] Fluoroquinolones are not licensed by the FDA for use in children due to the risk of fatalities [25] as well as permanent injury to the musculoskeletal system, with two ...