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Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and liver, which in turn can lead to diabetes.
Acid lipase disease or deficiency is a name used to describe two related disorders of fatty acid metabolism. Acid lipase disease occurs when the enzyme lysosomal acid lipase that is needed to break down certain fats that are normally digested by the body is lacking or missing. This results in the toxic buildup of these fats in the body's cells ...
Very low levels of the LAL enzyme lead to LAL deficiency. LAL deficiency typically affects infants in the first year of life. The accumulation of fat in the walls of the gut in early-onset disease leads to serious digestive problems including malabsorption, a condition in which the gut fails to absorb nutrients and calories from food.
In biochemistry, lipase (/ ˈ l aɪ p eɪ s, ˈ l aɪ p eɪ z / LY-payss, LY-payz) refers to a class of enzymes that catalyzes the hydrolysis of fats. Some lipases display broad substrate scope including esters of cholesterol , phospholipids , and of lipid-soluble vitamins [ 1 ] [ 2 ] and sphingomyelinases ; [ 3 ] however, these are usually ...
Lipoprotein lipase has been shown to interact with LRP1. [ 51 ] [ 52 ] [ 53 ] It is also a ligand for α2M , GP330 , and VLDL receptors. [ 23 ] LPL has been shown to be a ligand for LRP2 , albeit at a lower affinity than for other receptors; however, most of the LPL-dependent VLDL degradation can be attributed to the LRP2 pathway. [ 23 ]
Hepatic lipase (HL), also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of lipase, catalyzing the hydrolysis of triacylglyceride. Hepatic lipase is coded by chromosome 15 and its gene is also often referred to as HTGL or LIPC . [ 5 ]
The test, developed in the ’80s by the Oklahoma-based HR consulting firm Hogan Assessment Systems, uses data science paired with psychoanalysis to predict job performance based on in-depth ...
When lipase enzymes are phosphorylated, they can access lipid droplets and through multiple steps of hydrolysis, breakdown triglycerides into fatty acids and glycerol. Each step of hydrolysis leads to the removal of one fatty acid. The first step and the rate-limiting step of lipolysis is carried out by adipose triglyceride lipase (ATGL).