Ads
related to: letrozole fertility drug- Insurance & Coverage
See What Is Covered & Learn More
About What To Ask Your Provider.
- Doctor Visit Guide
Download a Doctor Discussion Guide
To Prepare For Your Appointment
- LGBTQ+ & Fertility
Explore Inclusive Resources &
Guidance That May Help.
- Guide to IVF
Learn More About What to Expect
From A IVF Treatment Therapy
- Diagnosis & Treatments
Understand The Various Treatment
Options & What To Ask Your RE.
- Fertility Challenges
Learn About Common Causes & Find
Out When To Consider Seeing An RE.
- Insurance & Coverage
Search results
Results From The WOW.Com Content Network
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer for post-menopausal women. [ 1 ] It was patented in 1986 and approved for medical use in 1996. [ 4 ]
Among all aromatase inhibitors, Letrozole is commonly used for improving female fertility. It works by inhibiting aromatase which is an enzyme that catalyses the conversion of androstenedione and testosterone to estrogen by hydroxylation. Hence, Letrozole inhibits the synthesis of estrogen. [18]
Aromatase inhibitors are a common fertility treatment to treat women with PCOS. A meta-analysis analyzing live birth rates for women with PCOS treated with clomiphene compared to letrozole found that letrozole resulted in higher live birth rates. [11] However, ovulation induction remains an off-label indication, which affects use.
Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained female infertility. In a multi-center study funded by the National Institute of Child Health and Development, ovarian stimulation with letrozole resulted in a significantly lower frequency of multiple gestation (i.e., twins or triplets) but also a lower frequency ...
India banned the usage of letrozole in 2011, citing potential risks to infants. [21] In 2012, an Indian parliamentary committee said that the drug controller office colluded with letrozole's makers to approve the drug for infertility in India. [22]
The liver is the main site of drug metabolism and the drug is metabolized by glucuronidation, hydroxylation and N-dealkylation. The metabolites are mainly excreted in the urine. [24] Letrozole has a standard daily dose of 2,5 mg and the drug has around 99,9% oral bioavailability. That means that the drug is absorbed fast and entirely.