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21846 Ensembl ENSG00000066056 ENSMUSG00000033191 UniProt P35590 Q06806 RefSeq (mRNA) NM_001253357 NM_005424 NM_011587 RefSeq (protein) NP_001240286 NP_005415 NP_035717 Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.33 – 118.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE ...
Angiopoietin proteins 1 through 4 are all ligands for Tie-2 receptors. Tie-1 heterodimerizes with Tie-2 to enhance and modulate signal transduction of Tie-2 for vascular development and maturation. These Tyrosine kinase receptors are typically expressed on vascular endothelial cells and specific macrophages for immune responses. [6]
In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). [1] Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2.
Biology is the scientific study of life. [1] [2] [3] It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. [1] [2] [3] For instance, all organisms are composed of at least one cell that processes hereditary information encoded in genes, which
Hemidesmosomes form rivet-like links between cytoskeleton and extracellular matrix components such as the basal laminae that underlie epithelia. Like desmosomes, they tie to intermediate filaments in the cytoplasm, but in contrast to desmosomes, their transmembrane anchors are integrins rather than cadherins. [8]
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The NFC wild-card game between the Los Angeles Rams and Minnesota Vikings is being moved to Arizona, the NFL announced Thursday. The game remains scheduled for Monday at 5 p.m. PT, but will now be ...
Zonula Occludin 1 (ZO-1) serves as the scaffolding protein for the tight junction. This means that it directly links the tight junction proteins to the f-actin cytoskeleton. In addition to anchoring claudins, occludin, and JAMs to the apical region of the cell membrane, ZO-1 has also been implicated in important cellular processes such as ...