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[76] [81] The discomfort can often be avoided by beginning at a low dose (1.0 to 1.7 g/day) and increasing the dose gradually, but even with low doses, 5% of people may be unable to tolerate metformin. [76] [82] Use of slow or extended-release preparations may improve tolerability. [82]
As noted, timing your metformin dosage is crucial for mitigating the risk — and overall severity — of side effects. But what are those side effects exactly? The most common side effects of ...
If metformin is causing GI side effects such as diarrhea or bloating, first try reducing the dose and taking it just once a day instead of twice a day, Dr. Gupta suggests. “You can also try ...
The type 2 diabetes drug Mounjaro has been recommended to help obese people lose weight on the NHS. ... recommended Mounjaro as an option for type 2 diabetics who could not tolerate metformin.
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
Patients are often unable to tolerate the theoretical MTD of a drug due to the occurrence of side-effects which are not innately a manifestation of toxicity (not considered to severely threaten a patient's health) but cause the patient sufficient distress and/or discomfort to result in non-compliance with treatment.
Ngo-Hamilton explained the issue becomes exacerbated for people who take Mounjaro, as this drug is more frequently used by individuals who cannot tolerate metformin (the most common drug to treat ...
Tolerability of a particular drug can be discussed in a general sense, or it can be a quantifiable measurement as part of a clinical study. Usually, it is measured by the rate of "dropouts", or patients that forfeit participation in a study due to extreme adverse effects.