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Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, [1] [2] and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also beginning to be prescribed to men on testosterone replacement therapy as a way to keep estrogen levels from spiking once doses of testosterone are introduced to their systems.
[4] [5] [6] Aromatase is responsible for the conversion of testosterone to estradiol. Blocking aromatase causes the body to decrease in levels of estradiol, which then results in increase of LH and consequently, testosterone. Since testosterone has myotropic activity and estradiol does not, elevated testosterone levels increase muscle mass.
Testosterone levels increase in adolescence after puberty and into early adulthood, ... , a derivative of clomiphene called enclomiphene, or aromatase inhibitors like anastrozole (Arimidex ...
And DHEA may increase testosterone — there’s a reason it’s an ingredient in male-enhancement products like ExtenZe. ... Aromatase inhibitors. Anticoagulant and antiplatelet drugs. Tamoxifen.
The increase in LH levels leads to an elevation in androgen and estrogen levels. [88] At a dosage of 150 mg/day, bicalutamide has been found to increase testosterone levels by about 1.5- to 2-fold (59–97% increase) and estradiol levels by about 1.5- to 2.5-fold (65–146% increase).
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