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In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...
TL;DR: "The 'right' dose is the dose that is both maximally tolerated and achieves individualized patient’s goals for good sugar and weight control," Dr. Shenoy says. "The right dose also helps ...
Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...
The Harris–Benedict equation (also called the Harris-Benedict principle) is a method used to estimate an individual's basal metabolic rate (BMR).. The estimated BMR value may be multiplied by a number that corresponds to the individual's activity level; the resulting number is the approximate daily kilocalorie intake to maintain current body weight.
Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...
However, it is also possible to approximately estimate BMR using several equations that factor in a person's age, sex, height, and weight. [18] Some of the most popular and accurate equations used to calculate BMR are the original Harris-Benedict equations, the revised Harris-Benedict equations, and the Mifflin St. Jeor equation. [19]
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The Estimated Energy Requirement, , is the estimated number of daily kilocalories, or Calories, an individual requires in order to maintain his or her current weight. For a person with a body mass of m {\displaystyle m} (kg), height of h {\displaystyle h} (m), age of a {\displaystyle a} (years) and Physical Activity PA {\displaystyle {\text{PA ...