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Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, [1] resulting in the formation of peroxide and hydroperoxide derivatives. [2] It occurs when free radicals , specifically reactive oxygen species (ROS), interact with lipids within cell membranes , typically polyunsaturated fatty ...
When a fatty acid oxidation disorder affects the muscles, it is a metabolic myopathy. Moreover, cancer cells can display irregular fatty acid metabolism with regard to both fatty acid synthesis [44] and mitochondrial fatty acid oxidation (FAO) [45] that are involved in diverse aspects of tumorigenesis and cell growth.
In biochemistry and metabolism, beta oxidation (also β-oxidation) is the catabolic process by which fatty acid molecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA.
Fatty acids exhibit reactions like other carboxylic acids, i.e. they undergo esterification and acid-base reactions. Fatty acids do not show a great variation in their acidities, as indicated by their respective pK a. Nonanoic acid, for example, has a pK a of 4.96, being only slightly weaker than acetic acid (4.76).
The autoxidation of unsaturated fatty acids causes them to crosslink to form polymers. [16] This phenomenon has been known since antiquity and forms the basis of drying oils, which were traditionally used to make many varnishes and paints. [17] Linseed oil, which is rich in polyunsaturated fats, is a prime example.
Oxidation by FAD; Hydration; Oxidation by NAD + Thiolysis; Production of acyl-CoA and acetyl-CoA; The final product of β-oxidation of an even-numbered fatty acid is acetyl-CoA, the entry molecule for the citric acid cycle. [3] If the fatty acid is an odd-numbered chain, the final product of β-oxidation will be propionyl-CoA.
Rancidification is the process of complete or incomplete autoxidation or hydrolysis of fats and oils when exposed to air, light, moisture, or bacterial action, producing short-chain aldehydes, ketones and free fatty acids.
Fatty acid catabolism begins in the cytoplasm of cells as acyl-CoA synthetase uses the energy from cleavage of an ATP to catalyze the addition of coenzyme A to the fatty acid. [6] The resulting acyl-CoA cross the mitochondria membrane and enter the process of beta oxidation .