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The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) and early stage cervical cancer discovered on colposcopic examination. In the UK, it is known as large loop excision of the transformation zone (LLETZ).
Endocervical curettage is a medical procedure used to extract cells of the endocervix to visualize under a microscope. Direct cervical visualization, colposcopy, and even endocervical colposcopy are not enough to fully analyze all areas of the endocervical epithelium and thus endocervical curettage is the method of choice in cases where this is necessary.
Cervical conization refers to an excision of a cone-shaped portion of tissue from the mucous membrane of the cervix. Conization is used for diagnostic purposes as part of a biopsy and for therapeutic purposes to remove pre-cancerous cells ( cervical intraepithelial neoplasia ) or early stage cervical cancer .
The main goal of colposcopy is to prevent cervical cancer by detecting and treating precancerous lesions early. Human Papillomavirus (HPV) is a common infection and the underlying cause for most cervical cancers. Smoking also makes developing cervical abnormalities more likely.
Cervical cancer typically develops from precancerous changes called cervical intraepithelial neoplasia over 10 to 20 years. [3] About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma, and a small number are other types. [4] Diagnosis is typically by cervical screening followed by a biopsy. [2]
A 2005 study found the sensitivity and specificity of cervicography for cervical intraepithelial neoplasia to be 72.3% and 93.2% respectively; [5] however, a 2007 study criticized the sensitivity figure as "likely... inflated" because the "gold standard" of colposcopy/biopsy may have missed cases of cervical intraepithelial neoplasia. [6]
Cervical cancer is a type of gynecological cancer that begins from cells lining the cervix, the lower part of the uterus. [14] Cervical cancer begins when the cells that line the cervix become abnormal and grow in a pattern that is atypical for non-cancerous cells. [14] Cervical cancer is typically first identified with an abnormal pap smear. [14]
Cervical cryotherapy. Treatment for CIN 1, mild dysplasia, is not recommended if it lasts fewer than two years. [20] Usually, when a biopsy detects CIN 1, the woman has an HPV infection, which may clear on its own within 12 months. Therefore, it is instead followed for later testing rather than treated. [20]