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Ribose-5-phosphate isomerase deficiency (RPID) is a rare human disorder caused by mutations in ribose-5-phosphate isomerase, an enzyme of the pentose phosphate pathway.With only four known cases – all diagnosed between 1984 and 2019 – RPI deficiency is the second rarest disease, with Fields condition being the rarest, affecting two known individuals, Catherine and Kirstie Fields.
Ribose-5-phosphate isomerase (Rpi) encoded by the RPIA gene is an enzyme (EC 5.3.1.6) that catalyzes the conversion between ribose-5-phosphate (R5P) and ribulose-5-phosphate (Ru5P). It is a member of a larger class of isomerases which catalyze the interconversion of chemical isomers (in this case structural isomers of pentose ).
The same review also showed the prevalence of hair loss increases with age — approximately 12 percent of women aged 20 and 29 years experience hair loss, while over 50 percent of women over the ...
The symptoms of female hair loss vary depending on which type of hair loss you have. You may notice sudden hair loss, gradual hair loss, or hair loss that gets better or worse over time.
Crystal structure of ribose 5-phosphate isomerase and ribose 5-phosphate complex in E. coli. R5P consists of a five-carbon sugar, ribose, and a phosphate group at the five-position carbon. It can exist in open chain form or in furanose form. The furanose form is most commonly referred to as ribose 5-phosphoric acid. [1]
This means even a small deficiency can increase our rate of hair shedding." She suggests including protein, complex carbohydrates, foods rich in iron, vitamin C, and vitamin B12 in every meal.