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Because of the prolonged survival, which was typically about 10 years in past decades, but which can extend to a normal life expectancy, the prevalence (number of people living with the disease) is much higher than the incidence (new diagnoses). [2] CLL is the most common type of leukemia in the UK, accounting for 38% of all leukemia cases.
Treatment includes radiation and chemotherapy. Early-stage indolent B-cell lymphomas can often be treated with radiation alone, with long-term non-recurrence. Early-stage aggressive disease is treated with chemotherapy and often radiation, with a 70–90% cure rate. [ 1 ]
Radiation therapy may be added, especially if chemotherapy does not seem sufficient on its own. [14] Radiation may cause other health problems later, such as breast cancer, and there is some debate about the best approach to it. [10] [3] FDG-PET scanning is not as useful for predicting treatment success in PMBCL as it is in other lymphomas. [10 ...
Recent studies showed that CNS chemotherapy provided results as favorable but with fewer developmental side effects. As a result, the use of whole-brain radiation has been more limited. Most specialists in adult leukemia have abandoned the use of radiation therapy for CNS prophylaxis, instead using intrathecal chemotherapy. [54] [8]
However, numerous approaches have been used to treat the disease. Patients with disease that is contained within a limited radiation field have been treated with radiation therapy to attain overall 10 year survival rates of 60-80%. However, one study found that radiation-treated patients had a relapse rate of 48%.
Studies indicate that radiation therapy (radio therapy) may reduce the risk of progression in adults. [18] [11] In one study, stage I-II patients treated with radiation therapy showed 10-year cause-specific survival of 98%, and the rate of developing radiotherapy-related second malignancies was not increased by the treatment (1% after 10 years ...
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