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The shelf life of ear drops varies with products generally needing to be discarded within 4 weeks after opening. [10] [11] With proper use and storage, ear drops should remain effective and safe until the expiration date printed in the medication package insert.
Prednisolone when delivered systemically can be found in the mother's breast milk, however, there is no data provided for the extent of prednisolone found in the system after administering eye drops. [29] [54] However, the presence of corticosteroids is recorded when they are administered systemically, and it could affect the fetus' growth. [54]
The labeled expiration date is a manufacturer's promise for a time until which the drug will have full efficacy and be safe as manufactured. [4] The labeled expiration date is not an indication of when a drug has become ineffective or unsafe to use. [4] Many drugs are effective for years after their expiration dates. [4]
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The period-after-opening symbol or PAO symbol is a graphic symbol that identifies the useful lifetime of a cosmetic product after its package has been opened for the first time. It depicts an open cosmetics pot and is used together with a written number of months or years.
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