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Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.
In most cases pineal TRb is diagnosed before the age of 5, but after the diagnosis of retinoblastoma. Non-pineal TRb, however, is often diagnosed simultaneous with retinoblastoma. Prognosis of patients with trilateral retinoblastoma is dismal, only a few patients have survived more than 5 years after diagnosis; all survivors were diagnosed with ...
19645 Ensembl ENSG00000139687 ENSMUSG00000022105 UniProt P06400 P13405 RefSeq (mRNA) NM_000321 NM_009029 RefSeq (protein) NP_000312 NP_000312.2 NP_033055 Location (UCSC) Chr 13: 48.3 – 48.6 Mb Chr 14: 73.42 – 73.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The retinoblastoma protein (protein name abbreviated Rb or pRb ; gene name abbreviated Rb, RB or RB1) is a tumor ...
An eye neoplasm is a tumor of the eye. [1] A rare type of tumor, [2] eye neoplasms can affect all parts of the eye, and can either be benign or malignant (), in which case it is known as eye cancer. [3]
Retinoblastoma is a rare form of eye neoplasm (found in the retina) that is mostly found in children, being the most common intraocular malignancy of infancy and childhood. The incidence is of one case per every 15,000 to 20,000 live births, and some of the most common symptoms of this disease are leukocoria and strabismus, iris rubeosis ...
5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_002893 NM_009031 RefSeq (protein) NP_001185648 NP_002884 NP_033057 Location (UCSC) Chr X: 16.84 – 16.87 Mb Chr X: 161.54 – 161.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. Function ...
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.
5934 19651 Ensembl ENSG00000103479 ENSMUSG00000031666 UniProt Q08999 Q64700 RefSeq (mRNA) NM_005611 NM_001323608 NM_001323609 NM_001323610 NM_001323611 NM_001282000 NM_001282001 NM_011250 RefSeq (protein) NP_001310537 NP_001310538 NP_001310539 NP_001310540 NP_005602 NP_001268929 NP_001268930 NP_035380 Location (UCSC) Chr 16: 53.43 – 53.49 Mb Chr 8: 91.8 – 91.85 Mb PubMed search Wikidata ...