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Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. [5] In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.
IL-6 had previously been classified as a proinflammatory cytokine. Therefore, it was first thought that the exercise-induced IL-6 response was related to muscle damage. [ 22 ] However, it has become evident that eccentric exercises are not associated with a larger increase in plasma IL-6 than exercise involving concentric “nondamaging ...
Pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α also trigger pathological pain. [1] While IL-1β is released by monocytes and macrophages, it is also present in nociceptive DRG neurons. IL-6 plays a role in neuronal reaction to an injury. TNF-α is a well known proinflammatory cytokine present in neurons and the glia.
It is rich in antioxidants, omega-3 fatty acids and vitamin D, all of which can help reduce inflammation. The crispy red potato slices and the creamy horseradish sauce add complementary textures.
1401 12944 Ensembl ENSG00000132693 ENSMUSG00000037942 UniProt P02741 P14847 RefSeq (mRNA) NM_000567 NM_001329057 NM_001329058 NM_001382703 NM_007768 RefSeq (protein) NP_000558 NP_001315986 NP_001315987 NP_001369632 NP_031794 Location (UCSC) Chr 1: 159.71 – 159.71 Mb Chr 1: 172.53 – 172.66 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse C-reactive protein (CRP) is an annular (ring ...
Interleukin 10 (IL-10) is a protein that inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. In structure, IL-10 is a protein of about 160 amino acids that contains four conserved cysteines involved in disulphide bonds. [33]
If a pregnant mother has high levels of interleukin-8, there is an increased risk of schizophrenia in her offspring. [23] High levels of Interleukin 8 have been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia. [24] IL-8 has also been implicated in the pathology of cystic fibrosis.
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