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Overview of Scleroderma. Scleroderma is an autoimmune disease that causes inflammation and fibrosis (thickening) in the skin and other areas of the body. When an immune response tricks tissues into thinking they are injured, it causes inflammation, and the body makes too much collagen, leading to scleroderma. Too much collagen in your skin and ...
Scleroderma is an autoimmune disease that causes inflammation and thickening in the skin and other areas of the body. This inflammation leads to areas of tight, hard skin. There are two major types of scleroderma: Localized scleroderma only affects the skin and the structures directly under the skin. Systemic scleroderma, also called systemic ...
Types of Osteogenesis Imperfecta. There are several types of OI, and different classifications are used based on the severity of the disease or on the nature of the underlying gene defect. Type I is the mildest and most common form of OI. Type II is the most severe form of OI. Other types of OI have symptoms that fall between Type I and Type II.
Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body. Lupus occurs when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation, and in some cases permanent tissue damage, which can be ...
Change over time. Some symptoms happen when the disease causes inflammation in organs. Symptoms of lupus can include: Arthritis, causing painful and swollen joints and morning stiffness. Fevers. Feeling tired often (fatigue). Rashes. Hair loss. Sores, which are usually painless, in the nose and mouth.
Evaluating how immunosuppressant and other medications can be used to help manage the symptoms and complications of scleroderma, particularly pulmonary complications. Exploring the many factors that lead to fibrosis to see if their development can be blocked. Determining how substances known as cytokines contribute to the disease process.
Ankylosing spondylitis is a type of arthritis that causes inflammation in the joints and ligaments of the spine. It may also affect peripheral joints like the knees, ankles, and hips. Normally, the joints and ligaments in the spine help us move and bend. If you have ankylosing spondylitis, the inflammation in the joints and tissues of the spine ...
Scleroderma. Locations of the 25 GRASP consortium centers. Scleroderma (systemic sclerosis) is a chronic, multi-system, autoimmune disease characterized by progressive fibrosis of the skin and internal organs. There is a health disparity in African Americans, who have an increased prevalence of scleroderma compared to European Americans.
There is no cure for scleroderma, but treatment can improve your quality of life. People with diffuse scleroderma face the most serious long-term outlook if they develop severe kidney, lung, digestive or heart problems. Fortunately, less than one-third of patients with diffuse disease develop these severe problems.
Rheumatoid arthritis (RA) is a chronic (long-lasting) disease that mostly causes pain, swelling, stiffness, and loss of function in joints. RA may cause you to feel unusually tired, to have occasional fevers, and to have a loss of appetite. Treatments can include medications, ongoing care from a doctor, and surgery.