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The most common side effects include nausea, vomiting, diarrhea, decreased appetite, constipation, upper abdominal discomfort, and abdominal pain. [ 10 ] [ 14 ] [ 19 ] Tirzepatide was approved for treatment of diabetes in the United States in May 2022, [ 10 ] [ 14 ] in the European Union in September 2022, [ 12 ] in Canada in November 2022 ...
Now, approved for weight loss under the name Zepbound, the drug is available in six doses—2.5, 5, 7.5, 10, 12.5, and 15 milligrams, according to Eli Lilly, which makes the injectable medication ...
Common side effects include daytime sleepiness, headache, nausea, and diarrhea. [11] More severe side effects include memory problems and hallucinations. [7] While flumazenil, a GABA A –receptor antagonist, can reverse zolpidem's effects, usually supportive care is all that is recommended in overdose. [20]
Higher risk of gastrointestinal side effects Due to the risk of potentially fatal lactic acidosis , contraindicated in people with shock ; with acute or chronic, moderate or severe kidney disease or at risk for impaired kidney function from intravenous dye ; and with acute or chronic metabolic acidosis
Hydrochlorothiazide, sold under the brand name Hydrodiuril among others, is a diuretic medication used to treat hypertension and swelling due to fluid build-up. [4] Other uses include treating diabetes insipidus and renal tubular acidosis and to decrease the risk of kidney stones in those with a high calcium level in the urine. [4]
Chlortalidone is considered a first-line medication for treatment of high blood pressure. [2] Some recommend chlortalidone over hydrochlorothiazide. [1] [15] A meta-analysis of randomized controlled trials found that chlortalidone is more effective than hydrochlorothiazide for lowering blood pressure, while the two drugs have similar toxicity.
Dapoxetine is absorbed and distributed rapidly in the body. Greater than 99% of dapoxetine is bound to the plasma protein. The mean steady-state volume is 162 L. Its initial half-life is 1.31 hours (30 mg dose) and 1.42 hours (60 mg dose), and its terminal half life is 18.7 hours (30 mg dose) and 21.9 hours (60 mg dose). [27] Metabolism
Diclofenac, sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. [6] [9] It can be taken orally (swallowed by mouth), inserted rectally as a suppository, injected intramuscularly, injected intravenously, applied to the skin topically, or through eye drops.