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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1 -antihistamine and it works by blocking certain effects of histamine , which produces its antihistamine and sedative effects.
The recommended dosage of Benadryl tablets for adults is 1 to 2 tablets every 4 to 6 hours, [1] and only 1 tablet every 4 to 6 hours for children under the age of 12. [2]The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States ...
After a later-deleted Facebook post by the teen's family member claimed that the death was the result of a "Benadryl challenge," news outlets reported on the dangers of the supposed social media trend. [33] [34] This prompted the FDA to release a statement on the dangers of high doses of diphenhydramine. [35]
But antihistamines like promethazine, doxylamine, and diphenhydramine can interfere with your body temperature regulation and tamp down on your ability to sweat, according to the CDC. Stimulants
The “Benadryl challenge” began circulating on the social media platform in 2020, at which point the Food and Drug Administration (FDA) issued a warning about the dangers associated with taking ...
Multiple teens have been hospitalized after ingesting up to 14 Benadryl doses at once, inspired by a TikTok challenge aimed at hallucinating. Experts say the activity could be deadly.
Synthetic compounds such as diphenhydramine (Benadryl) and dimenhydrinate (Dramamine) are deliriants. Nutmeg, although purportedly not as strong or as unpleasant as diphenhydramine or scopolamine, is considered a deliriant, due to its propensity to cause anticholinergic-like symptoms when taken in large doses. [30]
Diphenhydramine was the prototypical agent in this group. Significant anticholinergic adverse effects, as well as sedation, are observed in this group but the incidence of gastrointestinal adverse effects is relatively low. [4] [15] Diphenhydramine; Carbinoxamine; Doxylamine; Orphenadrine; Bromazine; Clemastine; Dimenhydrinate; Alkylamines