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The purpose of a dialyzer is to separate the analyte from interfering substances such as protein, whose large molecules do not go through the dialysis membrane but go to a separate waste stream. The reagents, sample and reagent volumes, flow rates, and other aspects of the instrument analysis depend on which analyte is being measured.
Kolff's first prototype dialyzer was developed in 1943, built from orange juice cans, used auto parts, and sausage casings. [3] Over a two-year span, Kolff had attempted to treat 15 people with his machine, but all had died. In 1945, Kolff successfully treated his first patient, a 67-year-old woman, from kidney failure using his hemodialysis ...
Automated coagulation machines or Coagulometers measure the ability of blood to clot by performing any of several types of tests including Partial thromboplastin times, Prothrombin times (and the calculated INRs commonly used for therapeutic evaluation), Lupus anticoagulant screens, D dimer assays, and factor assays.
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Gambro is a global medical technology company that manufactures products for dialysis treatment. The company is involved in developing, manufacturing and supplying products and therapies for kidney and liver dialysis, myeloma kidney therapy [clarify], and other extracorporeal therapies for chronic and acute patients.
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Hemofiltration is sometimes used in combination with hemodialysis, when it is termed hemodiafiltration. Blood is pumped through the blood compartment of a high flux dialyzer, and a high rate of ultrafiltration is used, so there is a high rate of movement of water and solutes from blood to dialysate that must be replaced by substitution fluid that is infused directly into the blood line.