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The hypothalamic-pituitary-thyroid axis. TRH can be seen in green. TRH is synthesized within parvocellular neurons of the paraventricular nucleus of the hypothalamus. [2] It is translated as a 242-amino acid precursor polypeptide that contains 6 copies of the sequence -Gln-His-Pro-Gly-, with both ends of the sequence flanked by Lys-Arg or Arg-Arg sequences.
TRH may cause nausea, vomiting and some patients experience an urge to urinate. [citation needed] Rarely, TRH may cause blood vessel constriction leading to hemorrhage in patients with pre-existing pituitary tumors. Accordingly, patients should be advised about the risks, albeit rare, of TRH testing. [2]
The TRH stimulates the anterior pituitary to produce thyroid-stimulating hormone (TSH). The TSH, in turn, stimulates the thyroid to produce thyroid hormone until levels in the blood return to normal. Thyroid hormone exerts negative feedback control over the hypothalamus as well as anterior pituitary, thus controlling the release of both TRH ...
TRH stimulates the thyrotropic cells through the use of a phospholipase C second messenger system. [1] TRH binds to a class A G protein-coupled receptor on the surface of a thyrotropic cell, which is known as the thyrotropin-releasing hormone receptor (TRHR). Strong hydrogen bonding interactions stabilize the binding of TRH to TRHR.
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
22045 Ensembl ENSG00000174417 ENSMUSG00000038760 UniProt P34981 P21761 RefSeq (mRNA) NM_003301 NM_013696 RefSeq (protein) NP_003292 NP_038724 Location (UCSC) Chr 8: 109.09 – 109.12 Mb Chr 15: 44.06 – 44.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone. The TRHR ...
Meaning Δ: diagnosis; change: ΔΔ: differential diagnosis (the list of possible diagnoses, and the effort to narrow that list) +ve: positive (as in the result of a test) # fracture: #NOF: fracture to the neck of the femur ℞ (R with crossed tail) prescription: Ψ: psychiatry, psychosis: Σ: sigmoidoscopy: x/12: x number of months x/40: x ...
This is a list of abbreviations used in medical prescriptions, including hospital orders (the patient-directed part of which is referred to as sig codes).This list does not include abbreviations for pharmaceuticals or drug name suffixes such as CD, CR, ER, XT (See Time release technology § List of abbreviations for those).